Recombinant Zoster Vaccine Toxicity and Immunogenicity Data in Rats

A non-clinical safety assessment of a recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02. Qian Yang published this dataset on figshare in 2026. It contains results from repeated dose toxicity and immunogenicity studies conducted in adult Sprague-Dawley rats.

Use Cases

• Assessing vaccine safety based on general health observations and histopathological evaluations mentioned in the description
• Evaluating immunogenicity based on cellular and humoral response assays mentioned in the description
• Determining no-observed-adverse-effect levels (NOAEL) based on the reported 1.0 mL per rat dose
• Comparing adjuvant effects based on data from the adjuvant control group mentioned in the description

Strengths

• Dataset includes a defined NOAEL of 1.0 mL per rat, equivalent to two human doses
• Safety assessment covers multiple endpoints: immunotoxicity, hematology, biochemistry, and histopathology
• Data supports progression to human clinical trials, indicating a systematic toxicology program

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is limited to a single animal model (Sprague-Dawley rats) and a specific vaccine formulation

Provenance

Source

figshare

Collection Method

Experimental study involving four subcutaneous doses of vaccine administered to rats, with safety and immunogenicity assays.

Freshness

Last updated 2026-05-22 05:35:48; freshness should be verified