Mycobacterium Tuberculosis Respiratory Chain Mutations Linked to Drug Resistance

A study of 13,402 Mycobacterium tuberculosis isolates, including 4,051 multidrug-resistant (MDR) and 1,044 single-drug resistant (SDR) strains, analyzed by Qiang Ji in 2026. Whole-genome sequencing was used to identify single nucleotide polymorphisms (SNPs) in respiratory chain genes associated with phylogenetic clustering and MDR development.

Use Cases

• Identifying genetic markers for drug resistance based on respiratory chain gene SNPs.
• Training predictive models for MDR tuberculosis classification based on mutation data.
• Analyzing phylogenetic clustering patterns of resistant tuberculosis strains.

Strengths

• Includes genomic data from 13,402 Mycobacterium tuberculosis isolates.
• Identifies specific SNPs in genes like atpH, cydA, and qcrB linked to MDR development.
• Analysis employs multiple statistical models (random forest, gradient boosting, GLMM).

Limitations

• Dataset is a 43.2 KB DOCX file; actual data structure and column definitions are unknown.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Qiang Ji.

Collection Method

Whole-genome sequencing performed on analyzed strains.

Time Range

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Freshness

Last updated 2026-05-20 04:38:19.

Geography

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