Retinoic Acid Effects on PRRSV Infection Transcriptomics

Figshare hosts a dataset from a study on retinoic acid's antiviral effects against porcine reproductive and respiratory syndrome virus (PRRSV). The data includes transcriptomic profiling results from porcine alveolar macrophages under infection and treatment conditions. The dataset is provided in a 1.4 MB XLS file under a CC BY 4.0 license.

Use Cases

• Analyze transcriptomic profiles to identify genes upregulated by retinoic acid treatment in uninfected porcine alveolar macrophages.
• Compare gene expression patterns between PRRSV-infected and ATRA-treated PRRSV-infected samples to study inflammation and lipid homeostasis pathways.
• Investigate the dual mechanism of antiviral action by correlating suppressed inflammatory activity with restored metabolic transport pathway signals.

Strengths

• Transcriptomic data provides molecular-level insight into host-virus-drug interactions.
• Dataset is openly shared under a permissive CC BY 4.0 license for reuse.
• Focus on primary porcine alveolar macrophages (PAMs) offers biologically relevant cell model data.

Limitations

• The dataset is small at 1.4 MB, indicating limited scope or sample depth.
• No column definitions or sample data are provided, complicating initial analysis.
• Data originates from a single controlled laboratory study, limiting generalizability.

Provenance

Source

Figshare, authored by Jintong Guo.

Collection Method

Generated from transcriptomic profiling of MARC-145 cells and primary porcine alveolar macrophages in a virology study.

Freshness

Last updated in March 2026.