Mouse Dentate Gyrus Gene Expression Patterns After Entorhinal Denervation

Whole-genome expression analysis from laser-microdissected mouse brain tissue at 1, 3, 7, 14, and 28 days post-injury. The dataset, created by Jessica Schlaudraff and last updated in May 2026, captures transcriptomic changes in the outer molecular and granule cell layers following perforant path transection. It identifies coordinated temporal programs involving synaptic reorganization, neuroinflammation, and compensatory plasticity.

Use Cases

• Model temporal dynamics of neuroinflammation based on the described upregulation of glial and inflammatory factors.
• Identify potential compensatory mechanisms in synaptic remodeling based on the reported upregulation of postsynaptic and dendritic membrane regulators.
• Analyze layer-specific transcriptional responses based on the separate profiling of the outer molecular layer and granule cell layer.
• Investigate downregulation of neurotransmission pathways based on the reported deficits in glutamatergic, GABAergic, and glycinergic signaling factors.

Strengths

• Data is derived from laser microdissection, allowing for layer-specific tissue isolation of the OML and GCL.
• Temporal resolution includes five time points (1, 3, 7, 14, 28 days) post-lesion.
• Whole-genome expression analysis provides a global view of transcriptome changes.
• License is CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific mouse model and injury protocol used.

Provenance

Source

Jessica Schlaudraff via figshare

Collection Method

Laser microdissection of mouse dentate gyrus tissue followed by whole-genome expression analysis.

Time Range

Observations taken at 1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:48; freshness should be verified.