Gene Expression in Uterine Leiomyoma and Myometrial Stem Cell Organ Cultures

A gene expression dataset from a study investigating transcriptional programs in uterine leiomyoma (fibroid) and myometrial stem cells during long-term organ culture. The dataset, shared by Paula Vázquez on figshare under a CC-BY-4.0 license, is stored in an XLSX file sized 251.1 KB. It was last updated in April 2026.

Use Cases

• Identify differential gene expression signatures between normal myometrium and MED12-mutant leiomyomas based on transcriptional profiles.
• Analyze pathways related to metabolic reprogramming, fibrosis, and immune response based on the described dysregulation of TGFB, KLF, and HOX genes.
• Investigate stem cell activation and proliferation markers like CD24, CD73, CD49b, and Ki67 based on the cell population findings.
• Model extracellular matrix (ECM) remodeling and integrin-mediated interactions based on the described pro-fibrotic signature.

Strengths

• Dataset is derived from a controlled organ culture experiment designed to recapitulate key molecular features of fibroids.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.
• File is a manageable 251.1 KB, allowing for quick inspection and download.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download to understand structure.
• The dataset's small size (251.1 KB) suggests a limited scope, likely containing summary results rather than raw sequencing data.
• Description metadata is limited; actual data quality and completeness require manual verification.

Provenance

Source

figshare, author Paula Vázquez.

Collection Method

Gene expression analysis from organ cultures of myometrium and leiomyoma tissues.

Time Range

Study period not specified; dataset last updated in 2026.

Freshness

Last updated 2026-04-22 05:35:54; freshness should be verified.

Geography

Geographic origin of samples not specified.