Human Bile Acid and Gut Microbiota Profiles for 200 Elderly and Young Participants

200 participants (100 elderly and 100 young) were enrolled in a cross-sectional study analyzing fecal and serum bile acids via LC-MS/MS and gut microbiota via 16S rRNA sequencing. The data, authored by Yumei Xu and last updated in April 2026, shows associations between bile acid alterations, microbiota dysbiosis, and markers of intestinal barrier dysfunction and chronic inflammation in aging.

Use Cases

• Correlating bile acid profiles with age-related gut microbiota shifts based on LC-MS/MS and 16S rRNA data.
• Investigating links between specific bile acids (e.g., LCA, CA) and inflammatory markers (IL-6, TNF-α) mentioned in the results.
• Modeling the relationship between primary/secondary bile acid ratios and indicators of intestinal barrier dysfunction.
• Exploring the role of microbiota capable of 7α-dehydroxylation in age-associated metabolic changes.

Strengths

• Includes data from 200 human participants with a balanced age group design (100 elderly, 100 young).
• Quantitative measurements from multiple assays: bile acids (LC-MS/MS), microbiota (16S rRNA), and cytokines (ELISA).
• Published under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The cross-sectional study design, noted in the conclusion, prevents establishing causal relationships.
• The dataset is small (35.8 KB), indicating limited scope and likely summary-level or aggregated data.

Provenance

Source

figshare, authored by Yumei Xu.

Collection Method

Data collected from human participants; bile acids quantified by LC-MS/MS, microbiota by 16S rRNA sequencing, cytokines by ELISA.

Time Range

null

Freshness

Last updated 2026-04-15 05:42:23; freshness should be verified.

Geography

null