Mouse Wound Infection Treatment Data with EM86-Loaded Nanofibers

Experimental data details the in vivo efficacy of an antimicrobial peptide-loaded nanofibrous dressing against multidrug-resistant Pseudomonas aeruginosa in BALB/c mice. The dataset contains results from a once-daily treatment over 4 days, including bacterial count reductions and scaffold characterization metrics. Samar Essam Metwally authored this dataset, last updated in April 2026.

Use Cases

• Analyze bacterial count reduction (P. aeruginosa SM016) in mouse wounds after treatment with EM86-loaded dressings.
• Correlate scaffold properties like fiber diameter (238 ± 78 nm) and swelling capacity (510%) with treatment outcomes.
• Evaluate peptide toxicity using the HSF IC50 value (>300 μg/mL) against its bactericidal activity.
• Study time-kill kinetics data showing EM86 killed Pseudomonas aeruginosa SM016 within 60 minutes.

Strengths

• Dataset includes specific, quantified results such as a 35 ± 18 μg EM86 loading dose and bacterial count P-values < 0.001.
• Provides multiple characterization metrics: fiber diameter, swelling capacity, and in vitro toxicity thresholds.

Limitations

• Extremely small dataset at 18.9 KB, indicating limited scope and likely few rows of summarized results.
• Data is confined to a single bacterial strain (Pseudomonas aeruginosa SM016) and one mouse model (BALB/c), limiting generalizability.
• No column-level data or sample records are provided, restricting detailed analysis.

Provenance

Source

Samar Essam Metwally via figshare.

Collection Method

Generated from laboratory experiments involving peptide synthesis, scaffold electrospinning, and in vivo mouse wound infection models.

Time Range

Covers a 4-day treatment period in the described experiment.

Freshness

Data reflects experiments concluded by 2026.