VEXAS Syndrome Clinical and Laboratory Features in 16 Chinese Patients

A single-center case series of 16 male VEXAS syndrome patients identified from 4512 consecutive patients with hematologic abnormalities at a Chinese academic hospital between June 2023 and July 2024. The dataset, authored by Xiang Ren, profiles clinical presentations, laboratory findings, bone marrow morphology, and UBA1 gene mutation variants. It was last updated on 2026-04 16.

Use Cases

• Characterizing the spectrum of hematological abnormalities in VEXAS syndrome based on reported diagnoses like CCUS, MDS, MGUS, primary myelofibrosis, and hemolysis-like disorder.
• Analyzing the correlation between UBA1 gene variants and clinical phenotypes based on the reported canonical and infrequent mutations.
• Studying the prevalence of systemic symptoms and multiorgan involvement in VEXAS syndrome based on reported constitutional symptoms, skin lesions, chondritis, and pulmonary infiltration.
• Evaluating treatment response patterns based on reported symptomatic relief from corticosteroids and variable hematologic responses to androgens and erythropoiesis-stimulating agents.

Strengths

• Includes detailed clinical and laboratory profiles for 16 confirmed VEXAS syndrome patients.
• Reports specific mutation frequencies, with canonical UBA1 pathogenic variants detected in 81.3% (13/16) of patients.
• Provides a clear temporal and geographic scope: data from a Chinese hospital collected between June 2023 and July 2024.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small (21.1 KB), representing a single-center cohort of 16 patients.
• Column names and sample data are unavailable; field semantics must be inferred after download.

Provenance

Source

figshare, authored by Xiang Ren.

Collection Method

Retrospective analysis of patient records at a Chinese academic hospital.

Time Range

June 2023 to July 2024.

Freshness

Last updated 2026-04-16 05:19:12; freshness should be verified.

Geography

China (single-center).