Schistosoma Mansoni Egg Secretome from Mouse Liver and Intestine Granulomas

A dataset of 149 parasite proteins identified via laser microdissection and mass spectrometry from infected mouse tissues. The data likely captures protein profiles from acute and chronic infection phases in both liver and small intestine granulomas. The dataset was published by Lucie Jedličková on figshare under a CC-BY-4.0 license.

Use Cases

• Identify core parasite proteins based on the conserved set of 149 proteins.
• Compare immunomodulator expression based on features like omega-1 and IPSE protein abundance.
• Analyze organ-specific protein profiles between liver and intestinal granulomas.
• Investigate temporal changes in protein repertoire between acute and chronic infection phases.

Strengths

• Dataset is derived from in situ tissue analysis via laser microdissection, providing a direct view of the egg secretome.
• Identifies a core set of 149 parasite proteins conserved across samples.
• Compares protein profiles across two organs (liver and intestine) and two infection phases (acute and chronic).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to a mouse model; applicability to human infection may require further validation.

Provenance

Source

figshare

Collection Method

Laser microdissection of periovular granulomas from infected mice followed by high-resolution mass spectrometry.

Freshness

Last updated 2026-05-15 05:47:21; freshness should be verified.