KCNB1 Regulatory Variants Associated with BMI in Admixed Brazilian Population

1,079 admixed Brazilian individuals were analyzed in a genome-wide association study identifying BMI-associated loci. Samantha Kuwada Teixeira published this dataset on figshare in May 2026. The research highlights ancestry-specific genetic mechanisms, with a prioritized variant enriched in individuals with African ancestry.

Use Cases

• Identify ancestry-informative genetic variants associated with BMI based on GWAS results
• Study the role of KCNB1 in adipogenesis and body composition based on functional assays
• Analyze regulatory activity of non-coding variants using epigenomic annotation data
• Compare genetic risk allele frequencies across different ancestral populations

Strengths

• Includes GWAS data from 1,079 admixed Brazilian individuals
• Integrates functional validation data from luciferase assays and mouse models
• Identifies three BMI-associated loci reaching genome-wide significance (p ≤ 5 × 10⁻⁸)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset size is 13.4 KB, indicating a very limited scope

Provenance

Source

Samantha Kuwada Teixeira

Collection Method

Genome-wide association study (GWAS) of BMI, followed by integrative analysis and functional assays.

Freshness

Last updated 2026-05-07 04:45:03; freshness should be verified

Geography

Admixed Brazilian population