aMAP Risk Score and Mortality in MASLD/MetALD/ALD Patients: NHANES 1999-2018 Cohort

A cohort study of 32,654 participants from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, authored by Peng-yang Li and last updated in April 2026. It investigates the association between the aMAP risk score and all-cause, cardiovascular, and cancer mortality in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), MetALD, and Alcohol-related Liver Disease (ALD). The analysis includes multivariable Cox models and an external validation cohort of 642 individuals from Southern China.

Use Cases

• Validate the aMAP score as a mortality predictor based on the described cohort study results.
• Assess non-linear risk relationships for liver disease subtypes based on the restricted cubic spline analysis mentioned.
• Compare mortality hazard ratios across MASLD, MetALD, and ALD subgroups based on the reported findings.
• Conduct external validation of clinical risk scores using independent hospital-based cohorts as described.

Strengths

• Includes 32,654 participants from a nationally representative survey (NHANES).
• Provides hazard ratios for mortality across three distinct liver disease classifications (MASLD, MetALD, ALD).
• Uses an external validation cohort of 642 individuals for additional support.
• Analyzes multiple mortality outcomes: all-cause, cardiovascular, and cancer.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data table is unknown, which may limit suitability assessment.
• The dataset is stored as a 20.5 KB DOCX file, suggesting it likely contains summary results rather than the raw underlying data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using multivariable Cox proportional hazards models, restricted cubic spline analysis, and Kaplan–Meier curves.

Time Range

NHANES data from 1999 to 2018, with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-04 24 13:49:19; freshness should be verified.

Geography

United States (NHANES) and Southern China (validation cohort).