ART Effects on Alveolar Macrophage Senescence and SARS-CoV-2 Response

Vinicius M. Fava's dataset contains results from a systems immunology study on the impact of continuous antiretroviral therapy (ART) on alveolar macrophages. The data, last updated on 2026-04-22, likely includes measurements of epigenetic and transcriptomic changes linked to a progressive senescence-like state. The study found these changes were duration-dependent and impaired the macrophage response to SARS-CoV-2 ex vivo challenge.

Use Cases

• Modeling the relationship between ART duration and senescence-like gene expression based on transcriptomic priming data.
• Analyzing coordinated gene regulatory networks in alveolar macrophages based on single nucleus sequencing results.
• Investigating the impact of ART on interferon signaling and viral response pathways based on SARS-CoV-2 challenge data.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting broad reuse.
• The description provides a detailed scientific context for the systems immunology approach used.
• File size is 77.5 KB, indicating a focused and likely manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (77.5 KB), indicating limited scope.

Provenance

Source

figshare, author Vinicius M. Fava

Collection Method

Systems immunology approach evaluating alveolar macrophages from people with HIV and people on PrEP.

Freshness

Last updated 2026-04-22 05:49:09; freshness should be verified.