Common Carp Cathepsin L Gene Expression and Immune Profiling Data

Nine cathepsin L paralogs in common carp show tissue-specific expression patterns, with some enriched at mucosal barriers and others in systemic immune hubs. The dataset contains gene expression profiles across tissues and during infection with the pathogen Sphaerospora molnari. Sagar Nayak published this analysis on figshare in April 2026.

Use Cases

• Analyze tissue-specific expression partitioning of ctsl.1A/B and ctslaA/B paralogs across mucosal barriers and systemic immune hubs.
• Model structural variation in protease loop architecture and active-site cleft geometry among the nine ctsl paralogs.
• Track temporal reprogramming of ctsl expression profiles during Sphaerospora molnari infection progression.
• Investigate the uncoupling of ctsl regulation from inflammatory cytokine expression dynamics in immune response.

Strengths

• Identifies nine distinct cathepsin L paralogs resulting from ancestral and lineage-specific duplications.
• Expression data spans multiple tissues and immune compartments, including blood and head kidney leukocytes.
• Includes analysis of expression dynamics during a defined infection time course.

Limitations

• Small dataset at 3.0 MB; specific sample size and row count are not provided.
• Data is presented in a DOCX document, requiring extraction for computational analysis.
• Analysis is specific to common carp, limiting direct applicability to other vertebrate models.

Provenance

Source

figshare, authored by Sagar Nayak.

Collection Method

Gene identification, expression profiling, and structural modeling from the common carp model.

Time Range

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Freshness

Last updated April 2026.

Geography

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