VZV Genotypes and gE Mutations Predicting Herpes Zoster Pain Outcomes

52 herpes zoster outpatients from Chongqing were enrolled, with 46 samples sequenced for viral genotypes and glycoprotein E mutations. The dataset likely contains immunological markers and clinical pain outcomes used to build a predictive model. Ying Shi authored this study, which was last updated on April 29, 2026.

Use Cases

• Predicting poor pain relief outcomes in herpes zoster patients based on gE-related variables.
• Analyzing associations between VZV genotypes (e.g., Clade 2) and host immune responses.
• Investigating the role of specific gE mutations (e.g., T→I substitution) in disease progression.
• Developing L1-regularized regression models for clinical stratification using immunological indicators.

Strengths

• Includes 46 sequenced samples from a cohort of 52 patients.
• The predictive model demonstrated good performance (AUC = 0.87; PR-AUC = 0.74).
• Provides specific mutation counts (average 13.46 ± 8.07 mutations and 5.00 ± 3.71 deletions).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the Chongqing cohort.

Provenance

Source

figshare

Collection Method

Clinical data and immunological indicators were collected from outpatients; VZV genotyping and gE mutation analysis performed via PCR and sequencing.

Freshness

Last updated 2026-04-29 05:58:15; freshness should be verified.

Geography

Chongqing, China