Table 6: Hub Genes in the Immune-Active Phase of Chronic Hepatitis B

Four hub genes—CCR5, IL10RA, KCNA3, and SLC24A4—were identified as characteristic of the immune-active phase of chronic hepatitis B. The data originates from integrated bioinformatics and machine learning analysis of transcriptomic and single-cell RNA sequencing datasets. Author Fangfang Li published the findings on figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Validate potential drug targets for hepatitis B based on the identified hub gene SLC24A4.
• Investigate correlations between gene expression and immune cell infiltration in liver tissue based on the described analysis.
• Replicate the machine learning pipeline for identifying disease-phase-specific biomarkers from transcriptomic data.
• Cross-reference the identified hub genes with other multi-omics datasets for chronic hepatitis B.

Strengths

• Results are validated using two independent single-cell RNA sequencing datasets (GSE182159 and GSE283471).
• The analysis integrates differential expression, weighted gene co-expression network analysis (WGCNA), and machine learning algorithms.
• Findings include western blot validation from clinical samples.

Limitations

• The dataset is very small at 11.3 KB, suggesting limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Fangfang Li.

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic dataset GSE230397 and scRNA-seq datasets.

Freshness

Last updated 2026-05-04 05:31:08.