Common Genes in Diabetic Nephropathy and Retinopathy from Transcriptome Analysis

206 common genes were identified by intersecting differentially expressed genes from diabetic nephropathy and retinopathy patient samples. The dataset includes 6 diagnostic genes for diabetic nephropathy and 4 for diabetic retinopathy, resulting from LASSO analysis of transcriptome data GSE185011. Author Juan He published this work on figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-04-28.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic complications using the 206 common genes.
• Constructing regulatory networks for diabetic retinopathy based on the described 111 TF-4mRNA-33miRNA network.
• Analyzing immune cell infiltration differences, such as the decreased central memory CD4 T cells in diabetic nephropathy groups.

Strengths

• Identifies a specific set of 206 common genes between two diabetic complications.
• Screens and lists specific diagnostic genes (6 for DN, 4 for DR) using LASSO analysis.
• Includes results from enrichment analyses (ClusterProfiler, Metascape) and gene set enrichment analysis (GSEA).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 22.7 KB, indicating limited scope.

Provenance

Source

figshare, author Juan He.

Collection Method

Analysis of transcriptome data GSE185011 using differential expression analysis (limma), intersection, enrichment analysis, LASSO, and immune cell infiltration analysis.

Freshness

Last updated 2026-04-28 05:24:48; freshness should be verified.