Integrated Stress Response Prognostic Genes for High-Grade Serous Ovarian Cancer

Four prognostic genes (NUP35, CASP3, BAG5, DNAJB1) identified for high-grade serous ovarian cancer via Mendelian randomization and RNA sequencing analyses. The dataset likely contains results from differential expression, Cox analysis, and risk model construction. The data was published by Qian Li on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Validate prognostic risk models for ovarian cancer based on the identified ISR-related genes.
• Explore drug sensitivity correlations based on the link between DNAJB1 expression and NPK76-II-72–1 inhibition concentration.
• Investigate epithelial cell differentiation dynamics based on the expression changes of BAG5 and DNAJB1.
• Perform pathway enrichment analysis based on the PPAR signaling pathway identified in both risk groups.

Strengths

• Identifies four specific prognostic genes (NUP35, CASP3, BAG5, DNAJB1) with experimental validation via RT-qPCR, western blotting, and immunohistochemical staining.
• Integrates multiple analytical methods mentioned in the description: Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing.
• Risk model was constructed and evaluated, accurately predicting patient prognosis according to the description.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (17.6 KB), suggesting limited scope or summary-level results.

Provenance

Source

figshare

Collection Method

Integrated analysis of HGSOC- and ISR-related data using differential expression, Mendelian randomization, and Cox analyses.

Freshness

Last updated 2026-05-05 05:25:08; freshness should be verified.