Integrated Multi-Omics Data for Sepsis Immune Dysregulation and Therapy

Table 6_Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction.xlsx contains integrated multi-omics data from a sepsis study. The dataset, authored by Jiawen Duan and shared under a CC-BY-4.0 license, was last updated on May 15, 2026. It likely contains results from scRNA-seq, miRNA-seq, and RNA-seq analyses used to design and validate small-molecule therapies.

Use Cases

• Analyzing immune cell population dynamics in sepsis based on scRNA-seq data mentioned in the description
• Investigating dysregulated inflammatory and regenerative pathways (e.g., Hippo/Wnt) based on multi-omics findings
• Evaluating the synergistic effects of dual-pathway small-molecule combinations (C1, C2) on survival and organ function
• Validating gene expression changes (e.g., Il1b, Il6, Nos2, Tnfa suppression) in response to therapy

Strengths

• The dataset is derived from integrated multi-omics analyses (scRNA-seq, miRNA-seq, RNA-seq), suggesting a multi-faceted view of sepsis
• The study design includes validation in both in vitro and in vivo sepsis models, indicating experimental rigor
• The description provides specific, quantitative results, such as improving 7-day survival in septic mice from 20% to 70%

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (10.2 KB), indicating it likely contains summary or processed results rather than raw omics data

Provenance

Source

Jiawen Duan

Collection Method

Integrated multi-omics datasets (scRNA-seq, miRNA-seq, blood/lung RNA-seq) analyzed to delineate immune cell dynamics and dysregulated pathways.

Freshness

Last updated 2026-05-15 04:22:29; freshness should be verified