Table 6_Integrated transcriptomic profiling of programmed cell death patterns unveils macr

A 21.4 KB dataset containing integrated bulk and single-cell transcriptomic analysis results for hepatic ischemia-reperfusion injury (HIRI). The data, authored by Manling Xie and last updated in May 2026, identifies 25 differentially expressed programmed cell death-related genes and 5 hub genes used in a risk prediction model. It further delineates 12 distinct programmed cell death patterns within the HIRI microenvironment.

Use Cases

• Training risk prediction models for hepatic ischemia-reperfusion injury based on the 5 identified hub genes (THBS1, MAP1LC3B, PPP1R15A, CXCL8, ZC3H12A).
• Analyzing macrophage-hepatocyte crosstalk mechanisms based on the described THBS1-CD47 signaling axis.
• Studying heterogeneity in programmed cell death patterns using the 12 distinct patterns identified from single-cell transcriptomic data.
• Validating gene expression signatures for apoptosis, anoikis, immunogenic cell death, NETosis, and pyroptosis in liver injury contexts.

Strengths

• Integrates analysis from four public Gene Expression Omnibus (GEO) datasets (GSE151648, GSE14951, GSE12720, GSE171539).
• Identifies a specific set of 5 hub genes validated through machine learning and single-cell analysis.
• Mechanistic findings, including the THBS1-CD47 axis, were validated with in vivo and in vitro experiments as described.

Limitations

• The dataset is very small (21.4 KB), suggesting it contains summary results or a single table rather than raw expression data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

Analysis derived from public GEO datasets; original data uploaded to figshare by Manling Xie.

Collection Method

Computational analysis of bulk and single-cell RNA sequencing data, combined with machine learning algorithms and experimental validation as described.

Freshness

Last updated 2026-05-19 04:22:41; freshness should be verified.