RGS4 Expression and Functional Data for a Proliferative SF-1 PitNET Subgroup

An integrated analysis of single-cell and bulk RNA sequencing data from Steroidogenic Factor-1 (SF-1) lineage Pituitary Neuroendocrine Tumors (PitNETs). The dataset, created by Changxi Han and last updated in April 2026, identifies a tumor subgroup characterized by high expression of the RGS4 gene and its role in promoting proliferation via p53 destabilization.

Use Cases

• Identify molecular subgroups within SF-1 lineage PitNETs based on integrated scRNA-seq and bulk transcriptomic data mentioned in the description.
• Investigate the correlation between RGS4 expression and clinical parameters like tumor size and proliferation index as described.
• Validate the functional role of RGS4 in tumor cell proliferation and apoptosis using the described experimental results.
• Explore the RGS4-p53 axis as a potential therapeutic target for a subset of pituitary tumors.

Strengths

• Dataset is derived from an integrated analysis of both single-cell and bulk RNA sequencing data, as described in the methods.
• Functional validation of the top candidate gene RGS4 is supported by gain/loss-of-function experiments and pharmacological inhibition described in the study.
• The dataset has a clear open license (CC-BY-4.0) and is hosted on the figshare platform.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (22.1 KB), indicating limited scope, likely containing summary or key results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Integrated analysis of scRNA-seq and bulk transcriptomic datasets from SF-1 lineage PitNETs, followed by functional experiments in cell lines.

Freshness

Last updated 2026-04-22 05:49:45; freshness should be verified.