Virtual Memory CD8 T Cell Response to Chronic Viral Infection in Mice

A 9.4 KB Excel file from figshare, authored by Yamato Sajiki and last updated in May 2026. The dataset likely contains experimental results comparing the adaptability of virtual memory and naïve CD8 T cells during chronic lymphocytic choriomeningitis virus infection in a mouse model. It supports findings on impaired exhaustion programming and reduced stem-like cell populations in virtual memory T cells.

Use Cases

• Compare T cell subset responses based on the described phenotypes of VM and naïve-derived cells.
• Analyze the relationship between TOX expression and TCF1+ stem-like cell generation mentioned in the description.
• Investigate the efficacy of PD-1 blockade on different T cell populations based on the reported limited expansion of VM-derived cells.
• Model T cell fate decisions during chronic infection using the described differentiation into KLRG1+PD-1- cells.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The 9.4 KB file size suggests a focused, manageable dataset for targeted analysis.
• The description provides a detailed biological context for the likely experimental measurements.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (9.4 KB), indicating limited scope.

Provenance

Source

figshare, author Yamato Sajiki.

Collection Method

Likely contains experimental data from a chronic lymphocytic choriomeningitis virus infection mouse model, as described.

Freshness

Last updated 2026-05-22 09:48:23; freshness should be verified.