Macrolide Resistance Trajectories for Bordetella Pertussis Under Erythromycin Exposure

Three clinical macrolide-susceptible Bordetella pertussis isolates were subjected to stepwise erythromycin induction. The dataset includes phenotypic readouts such as antimicrobial susceptibility testing, growth and biofilm assays, and ELISA measurements of virulence factors. It was authored by Kaichong Jiang and last updated on 2026-04 17.

Use Cases

• Modeling resistance trajectory divergence based on genetic background.
• Analyzing associations between genomic alterations and phenotypic changes under antibiotic exposure.
• Comparing growth and biofilm formation differences across antibiotic-exposed lineages.
• Investigating variant accumulation in efflux-associated loci versus rRNA substitutions.

Strengths

• Data is derived from three distinct clinical genetic backgrounds, allowing for comparative analysis.
• Includes multiple phenotypic readouts: MIC, growth, biofilm, and ELISA for five factors (PT, FHA, LPS, DHFS, DHFR).
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 12.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Stepwise erythromycin induction of three parental isolates, tracked by whole-genome sequencing and phenotypic assays.

Time Range

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Freshness

Last updated 2026-04-17 05:20:58.

Geography

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