Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

A rat model study provides integrated transcriptome and metabolome profiles of the cerebral cortex following subarachnoid hemorrhage (SAH). Haoran Lu published the dataset on figshare in April 2026, containing results from whole transcriptome sequencing and untargeted metabolomics assays. The data includes counts of differentially expressed genes and metabolites at 1-day and 7-day post-SAH time points.

Use Cases

• Identify immune and inflammatory pathway dysregulation based on transcriptomic analysis of differentially expressed genes.
• Investigate metabolic pathway alterations based on the analysis of differentially expressed metabolites in pathways like Arginine and proline metabolism.
• Explore potential therapeutic targets for SAH based on the integrated analysis of gene and metabolite profiles.
• Validate findings related to oxidative stress and blood-brain barrier disruption based on the described metabolite associations.

Strengths

• Dataset integrates two omics layers, reporting 982 differentially expressed genes and 540 differentially expressed metabolites at the 1-day post-SAH time point.
• Specific biological pathways implicated, such as Complement and coagulation cascades and Arginine and proline metabolism, are identified.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download to understand data structure.
• The dataset is very small at 100.4 KB, indicating limited scope, likely containing summary results rather than raw sequencing data.
• Data is derived from a controlled rat model, which may limit direct translation to human pathophysiology.

Provenance

Source

figshare, author Haoran Lu.

Collection Method

Data generated via whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex samples.

Time Range

Samples likely collected at specific post-SAH time points (1 day and 7 days) versus a sham group.

Freshness

Last updated 2026-04-28 14:40:44; freshness should be verified.