Differentially Expressed MicroRNAs in Canine Visceral Hemangiosarcoma FFPE Tissues

A dataset of microRNA differential expression analysis from formalin-fixed, paraffin-embedded tissues of 24 dogs with visceral hemangiosarcoma and 12 non-neoplastic controls. The study identified 67 and 71 differentially expressed miRNAs in splenic and cardiac tumors, respectively, with 13 validated by RT-qPCR. The data was published by Laura Machado Ribas on figshare in March 2026.

Use Cases

• Identify potential diagnostic biomarkers for canine hemangiosarcoma based on validated differentially expressed miRNAs.
• Perform pathway enrichment analysis based on the oncogenic signaling pathways (PI3K-Akt, MAPK, HIF-1, Ras) mentioned in the results.
• Compare miRNA expression profiles between splenic and cardiac tumor types based on the 18 shared miRNAs.
• Assess the utility of archived FFPE tissues for biomarker discovery as highlighted in the discussion.

Strengths

• Includes data from 36 canine samples (24 tumor, 12 control).
• Results validated by RT-qPCR for 13 miRNAs, showing strong concordance with sequencing.
• Pathway enrichment analysis for validated miRNAs is provided.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 10.4 KB, indicating limited scope.

Provenance

Source

figshare, author Laura Machado Ribas.

Collection Method

Analysis of FFPE tissues using small RNA sequencing and quantitative PCR.

Time Range

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Freshness

Last updated 2026-03-17 14:39:57; freshness should be verified.

Geography

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