Mouse Lung Proteome Data for Millettia Speciosa Asthma Treatment Study

179 differentially expressed proteins identified in a mouse model of allergic asthma treated with the herb Millettia speciosa. The dataset includes proteomic analysis revealing complete suppression of the eosinophil-recruiting chemokine CCL24. It was authored by Hangrui Yang and last updated on June 3, 2026.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in allergic inflammation based on the described suppression.
• Analyze immunometabolic pathway modulation based on described changes in complement, lipid transport, and PPAR signaling.
• Validate hub protein networks in lung tissue based on identified proteins like Alb, Apoe, and Apoa1.

Strengths

• Includes 179 differentially expressed proteins identified via high-resolution data-independent acquisition proteomics.
• Findings are integrated with cytokine profiling from bronchoalveolar lavage fluid, showing reductions in IgE, IL-4, IL-5, and IL-6.
• Dataset is openly shared under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 859.8 KB, indicating a limited scope.

Provenance

Source

figshare

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics from an ovalbumin-induced mouse model of allergic asthma.

Freshness

Last updated 2026-06-03 07:42:24; freshness should be verified.