NGF Administration Effects on GnRH and Hormone Levels in Aging SAMP8 Mice

Data from a study on the effects of nerve growth factor (NGF) administration in male senescence-accelerated mouse P8 (SAMP8) models. The dataset likely contains measurements of serum hormone levels (LH, FSH, testosterone) at multiple time points, along with immunofluorescence and transcriptomic data related to GnRH neuron differentiation. The dataset was authored by Jiao Luo and last updated on 2026-04-24.

Use Cases

• Analyze the temporal effects of NGF dosage on serum LH, FSH, and testosterone levels based on measurements taken at 8h, 24h, 96h, 7d, and 10d post-injection.
• Investigate the relationship between NGF administration and GnRH immunoreactivity/Sox2 co-localization in the OVLT brain region based on immunofluorescence phenotypic readouts.
• Study signaling pathways involved in NGF-induced differentiation of hypothalamic neural stem cells into a GnRH-associated phenotype based on transcriptomic profiling and qPCR data.

Strengths

• Data is derived from a controlled in vivo study with three distinct NGF dosage levels (6.25, 12.5, and 25 μg/kg).
• Hormone measurements were taken at five specific time points post-injection, providing a temporal profile.
• The study employed multiple methodological approaches, including in vivo hormone assays, immunofluorescence, in vitro 3D culture, and transcriptomics.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (11.1 KB), indicating limited scope, likely containing summary or key result tables rather than raw experimental data.

Provenance

Source

figshare, authored by Jiao Luo.

Collection Method

Data likely originates from laboratory experiments on SAMP8 mice and primary cell cultures, as described in the methods.

Freshness

Last updated 2026-04-24 05:40:49; freshness should be verified.