Acute Gouty Arthritis Immune Cell and Plasma Protein Signatures

Peng Zhang's dataset on figshare contains results from a multi-omics study of acute gouty arthritis, last updated in 2026. The data likely includes findings from Mendelian randomization, CyTOF immune profiling, single-cell RNA-seq re-analysis, and plasma proteomics from Chinese cohorts. The study identified peripheral CD4+ naïve T cell remodeling and MMP1-associated inflammatory signatures as potential features of acute flares and recurrence risk.

Use Cases

• Validate genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results.
• Investigate inflammatory transcriptional features in CD4+ naïve T cells during acute flares based on single-cell RNA-seq re-analysis.
• Assess the exploratory potential of plasma MMP1 levels for recurrence risk stratification in acute gouty arthritis patients.

Strengths

• Data integrates findings from multiple methodologies: bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq, and plasma proteomics.
• Plasma proteomic analysis was performed on independent training (n=40) and validation (n=64) cohorts.
• The dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 10.5 KB, indicating limited scope or summary-level results.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Peng Zhang.

Collection Method

Integrated analysis using bidirectional Mendelian randomization, CyTOF immune profiling, single-cell transcriptomic re-analysis, and plasma proteomics (Olink platform).

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.

Geography

Study cohorts include individuals of European ancestry (for GWAS) and Chinese cohorts (for immune profiling and proteomics).