Table 6_Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorot

A dataset from a 2026 figshare upload by Riccardo Galasso, containing physicochemical profiles of antibody CDR3-VH clonotypes. It describes a shared set of 113 enriched CDR3-VH sequences identified through NGS-guided phage display against phosphorothioate-modified antisense oligonucleotides. The data includes descriptors such as charge, aromatic residue patterns, length distribution, theoretical pI, and hydrophobicity.

Use Cases

• Identifying convergent physicochemical signatures in antibody repertoires based on the described CDR3-VH profiles.
• Prioritizing candidate antibody binders for polyanionic targets based on the shared enriched clonotype set.
• Analyzing repertoire focusing and clonal dominance in phage display selections using the described NGS-guided framework.

Strengths

• Defines a specific shared set of 113 CDR3-VH clonotypes associated with target recognition.
• Includes multiple physicochemical descriptors per sequence, such as charge, pI, and hydrophobicity.
• Data is derived from a described NGS and phage display methodology with functional validation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare, author Riccardo Galasso.

Collection Method

Generated via next-generation sequencing-guided phage display and bioinformatic analysis of antibody repertoires.

Freshness

Last updated 2026-05-29 04:50:48; freshness should be verified.