Placental Transcriptome Profiles for Congenital Chagas Disease Transmission

RNA-seq data from placental tissues of newborns with congenital Chagas disease, exposed but uninfected, and unexposed controls. The dataset includes differential gene expression results for genes like CEMIP, PRRX1, and CGB5, as well as gene set and cell type enrichment analyses. Sofia Apodaca published the data on figshare under a CC-BY-4.0 license, with a last update in March 2026.

Use Cases

• Identify gene expression signatures associated with vertical transmission based on comparisons between infected, exposed, and control placental tissues.
• Analyze the role of extracellular matrix and cell adhesion pathways in congenital disease using the reported differential expression of CEMIP, CADM3, and CDH11.
• Investigate the enrichment of specific placental cell types, such as extravillous trophoblasts and syncytiotrophoblasts, in transmitting versus non-transmitting cases.
• Validate co-expression network hubs like ENPP1 and SLC16A10 as potential key regulators in the placental response to Trypanosoma cruzi infection.

Strengths

• Data is derived from a transcriptomic (RNA-seq) analysis, a high-resolution molecular profiling technique.
• Analysis includes multiple comparisons: congenitally infected vs. unexposed, exposed vs. unexposed, and infected vs. exposed.
• Findings are linked to specific biological processes like ECM remodeling and cell adhesion, with named genes and pathways.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is very small (39.0 KB), suggesting it contains summary results rather than raw sequencing reads or a full expression matrix.
• Row count and column-level documentation are unknown, limiting assessment of data structure and granularity.
• The description does not specify the sample size (number of placentas analyzed), a key factor for statistical power.

Provenance

Source

Sofia Apodaca via figshare.

Collection Method

Transcriptomic analysis (RNA-seq) of placental tissues from deliveries grouped by infection status.

Freshness

Last updated 2026-03-18 06:43:03.