Mendelian Randomization Study on Immune Cells, Metabolites, and Liver Cancer

A genetic association study by Zhipeng Ye, published on figshare in 2026, investigates causal links between immune cell profiles, blood metabolites, and intrahepatic cholangiocarcinoma. The dataset, 102.3 KB in size, contains results from a two-sample Mendelian randomization analysis with experimental validation. It identifies specific immune traits and metabolites like N-acetylleucine as risk factors and mediators for cancer development.

Use Cases

• Validate causal relationships between immune cell phenotypes and cancer risk based on Mendelian randomization results.
• Investigate the mediating role of blood metabolites like N-acetylleucine and fructosyllysine in cancer pathways.
• Design in vitro experiments targeting metabolic axes such as DLAT-leucine based on the identified genetic associations.
• Perform sensitivity analyses for horizontal pleiotropy and heterogeneity in genetic epidemiology studies.

Strengths

• Results include specific odds ratios and confidence intervals (e.g., OR = 1.0005 for activated CD4 regulatory T cells).
• Analysis employed strict sensitivity checks for pleiotropy and heterogeneity, as noted in the description.
• Findings are supported by in vitro experimental validation in HuCC-T1 and RBE cell lines.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (102.3 KB), indicating limited scope, likely containing summary results rather than raw genetic data.

Provenance

Source

figshare

Collection Method

Two-sample Mendelian randomization analysis with mediation analysis and in vitro cell experiments.

Freshness

Last updated 2026-05-22 06:10:30; freshness should be verified.