A non-clinical safety assessment of a recombinant zoster vaccine (CHO cell) formulated with adjuvant BC02. The dataset likely contains results from repeated dose toxicity and immunogenicity studies in adult Sprague-Dawley rats, including general health observations, hematological and biochemical profiling, and histopathological evaluations. The data was uploaded by Qian Yang on figshare in May 2026.
Use Cases
- Assessing vaccine safety based on general health observations and histopathological evaluations mentioned in the description
- Evaluating immunogenicity based on cellular and humoral response assays described
- Determining no-observed-adverse-effect levels (NOAEL) based on toxicology data
- Comparing adjuvant effects using data from the adjuvant control group referenced
Strengths
- The dataset is associated with a systematic toxicology program supporting progression to human clinical trials
- The NOAEL was determined at 1.0 mL per rat, equivalent to two human doses
- The vaccine elicited strong cellular and humoral responses, indicating favorable immunogenicity
Limitations
- Column-level documentation is absent; field semantics must be inferred after download
- Row count is unknown, which may limit suitability assessment
- The dataset is 12.6 KB, indicating a very limited scope
Provenance
- Source
- figshare
- Collection Method
- Likely contains experimental data from a non-clinical safety assessment study.
- Freshness
- Last updated 2026-05-22 05:35:47; freshness should be verified