Retinoic Acid Antiviral Effects on PRRSV Infection Transcriptomics

Figshare hosts a 546.4 KB XLS file containing transcriptomic data from a study on retinoic acid's antiviral effects. The dataset, authored by Jintong Guo, includes results from experiments on porcine alveolar macrophages infected with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). It supports findings that all-trans retinoic acid inhibits viral infection by modulating immune signaling and metabolic pathways.

Use Cases

• Analyze transcriptomic profiles to identify genes upregulated by ATRA treatment in uninfected PAMs.
• Compare gene expression patterns between PRRSV-infected and ATRA-treated PAMs to study inflammation attenuation.
• Investigate alterations in lipid homeostasis pathways from transcriptomic data of infected versus treated cells.

Strengths

• Data originates from a peer-reviewed experimental study with defined methods for transcriptomic profiling.
• The 546.4 KB XLS file provides structured experimental results from two cell types: MARC-145 cells and primary porcine alveolar macrophages.
• Dataset is openly licensed under CC BY 4.0, permitting reuse with attribution.

Limitations

• The dataset is small in scale at 546.4 KB, indicating limited raw data or processed summary results rather than full sequencing files.
• Sample data and column definitions are unavailable, complicating direct analysis without consulting the source publication.
• Data is specific to in vitro cell studies (PAMs and MARC-145), limiting direct applicability to in vivo or clinical contexts.

Provenance

Source

Jintong Guo, via figshare.

Collection Method

Generated from laboratory experiments evaluating antiviral efficacy and transcriptomic profiling of porcine alveolar macrophages.

Freshness

Last updated March 24, 2026.