Single-Cell Transcriptomic Atlas of Halo Nevi Versus Normal Nevi

A single-cell RNA sequencing dataset comparing halo nevi and normal nevi, created by Wenxuan Gao and last updated in May 2026. The data identifies ten canonical skin cell types and five melanocyte subclusters, revealing CD8+ T cell activation and melanocyte-intrinsic pathways in autoimmune destruction.

Use Cases

• Identify activated immune cell populations based on the description of CD8+ T cell infiltration and interferon response.
• Compare gene expression pathways in melanocyte subclusters based on the reported upregulation of antigen-presenting molecules and interferon-stimulated genes.
• Investigate shared pathogenic mechanisms with vitiligo based on the comparative analyses mentioned in the description.

Strengths

• Includes integrated single-cell RNA sequencing and immunofluorescence staining data, as described.
• Provides a comparative analysis of two biological conditions: halo nevi versus normal nevi.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (151.3 KB), indicating limited scope or a highly processed subset.

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing (scRNA-seq) performed on clinical samples.

Time Range

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Freshness

Last updated 2026-05-14 08:46:15; freshness should be verified.

Geography

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