Mouse Dentate Gyrus Gene Expression Patterns Following Entorhinal Denervation

Jessica Schlaudraff's dataset contains transcriptomic data from the mouse dentate gyrus after perforant path transection. Whole-genome expression analysis was performed on tissue from the outer molecular layer and granule cell layer isolated at 1, 3, 7, 14, and 28 days post-lesion. The dataset was last updated on 2026-05-19.

Use Cases

• Analyze temporal dynamics of glial activation based on reactive astrogliosis and microgliosis mentioned in the description
• Model compensatory synaptic remodeling based on postsynaptic and dendritic membrane regulators like Lyn and Gabarap
• Study injury-induced metabolic adaptation based on late downregulations of respiratory factors
• Investigate synaptic adhesion changes based on mediators like Lingo2, Lrrtm1, and Cadm2
• Track neurotransmitter signaling deficits based on glutamatergic and GABAergic receptor changes

Strengths

• Data spans five distinct time points (1, 3, 7, 14, and 28 days post-lesion)
• Focuses on two specific brain layers (outer molecular layer and granule cell layer)
• Includes specific fold-change measurements for key genes (e.g., Sema3e to 60%, Nrp1 3-fold)
• License is CC-BY-4.0, facilitating open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect experimental bias inherent to the specific mouse model and lesion technique

Provenance

Source

figshare

Collection Method

Whole-genome expression analysis on laser-microdissected tissue from mouse dentate gyrus following perforant path transection.

Time Range

Observations from 1 to 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:48; freshness should be verified