Temporal Transcriptional Dynamics in a Cutaneous Leishmaniasis Mouse Model

A longitudinal transcriptomic analysis of skin lesions and draining lymph nodes in a BALB/c mouse model infected with Leishmania braziliensis. The dataset includes bulk RNA sequencing data from six time points spanning 2 hours to 77 days post-infection. It was authored by Jessica Lobo-Silva and last updated on 2026-05-12.

Use Cases

• Identify stage-specific gene expression modules based on longitudinal sampling.
• Analyze conserved inflammatory pathways between mouse and human disease based on cross-species comparison.
• Discover host-directed therapeutic targets based on conserved non-coding RNAs and epigenetic regulators.
• Characterize gene co-expression networks associated with tissue damage and healing based on network analysis.

Strengths

• Longitudinal design with six distinct time points from 2 hours to 77 days post-infection.
• Cross-species validation showing mouse lesions recapitulate 77% of inflammatory pathways from human CL.
• Identifies 16 conserved microRNAs and 12 shared epigenetic regulators as potential therapeutic targets.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a specific mouse model (BALB/c ear dermal model), which may not capture all aspects of human disease.

Provenance

Source

figshare

Collection Method

Bulk RNA sequencing performed on skin lesions and draining lymph nodes from infected mice.

Time Range

Data collected from 2 hours to 77 days post-infection.

Freshness

Last updated 2026-05-12 04:20:10; freshness should be verified.