Mouse Wound Infection Data for Antimicrobial Peptide-Loaded Nanofibers

Data from a 2026 study evaluates an antimicrobial peptide-loaded nanofibrous dressing for treating multidrug-resistant Pseudomonas aeruginosa infections in BALB/c mice. The dataset includes results from in vivo testing over a 4-day treatment period, showing significant bacterial count reduction. Samar Essam Metwally authored this research, which is shared under a CC-BY-4.0 license.

Use Cases

• Analyze bacterial count reduction (P. aeruginosa SM016) in mouse wounds after treatment with EM86-loaded nanofibers.
• Compare swelling capacity (510%) and fiber diameter (238 ± 78 nm) metrics of SA/PVA nanofibrous scaffolds.
• Evaluate toxicity data, such as IC50 (> 300 μg/mL) for human skin fibroblasts, to assess peptide safety.
• Correlate EM86 loading amount (35 ± 18 μg) with in vivo bactericidal activity outcomes.

Strengths

• Includes specific in vivo efficacy metrics, such as P. aeruginosa count reduction (P < 0.001) after 4 days.
• Reports concrete material properties like nanofiber mean diameter (238 ± 78 nm) and swelling capacity (510%).

Limitations

• Dataset is very small (27.4 KB), indicating limited scope, likely a summary table rather than raw experimental data.
• No column names or sample data are provided, limiting direct analysis.

Provenance

Source

Samar Essam Metwally via figshare.

Collection Method

Generated from laboratory experiments involving peptide design, nanofiber synthesis, and in vivo mouse model testing.

Time Range

Study published in 2026.

Freshness

Last updated in April 2026.