A dataset of 149 parasite proteins identified as the in vivo excretory/secretory repertoire of Schistosoma mansoni eggs. The data was generated by Lucie Jedličková using laser microdissection and mass spectrometry on granuloma microenvironments from infected mice during acute and chronic infection phases. The dataset was last updated on May 15, 2026.
Use Cases
- Identify core parasite proteins for vaccine or diagnostic target discovery based on the conserved set of 149 proteins.
- Compare organ-specific host immune responses based on protein profiles from liver versus intestinal granulomas.
- Model temporal changes in parasite protein expression based on data from acute and chronic infection phases.
- Investigate differences in egg fate and tissue context based on protein composition patterns described.
Strengths
- Identifies a core set of 149 parasite proteins, providing a specific quantitative measure.
- Provides in situ characterization from host tissues, a methodological strength noted in the description.
- Compares protein profiles across two organs (liver, intestine) and two infection phases (acute, chronic).
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is small in size (41.6 KB), indicating limited scope.
Provenance
- Source
- figshare
- Collection Method
- Laser microdissection of periovular granulomas from infected mice followed by high-resolution mass spectrometry.
- Freshness
- Last updated 2026-05-15 05:47:20; freshness should be verified.