Plasma Exosomal Protein Profiles for Intrahepatic Cholestasis of Pregnancy

Yuxuan Jiang's proteomics dataset contains quantitative profiles of differentially expressed proteins in plasma exosomes from pregnant women. SWATH proteomics identified 109 and 46 differential proteins in total and placenta-derived exosomes, respectively, from 35 subjects including moderate and severe ICP cases and healthy controls. The data was published on figshare in April 2026.

Use Cases

• Identify diagnostic protein biomarkers for intrahepatic cholestasis of pregnancy based on differential expression analysis.
• Investigate complement activation and blood coagulation pathways in pregnancy disorders using the protein lists.
• Validate hub proteins like HRG, VWF, and PIGR as potential targets for stratified intervention.
• Explore fetal stress response mechanisms linked to elevated maternal bile acids using exosomal proteomic data.
• Compare protein profiles between total exosomes and placenta-derived exosomes to understand disease pathogenesis.

Strengths

• Includes proteomic data from 35 pregnant women, comprising 10 moderate ICP, 10 severe ICP, and 15 healthy controls.
• SWATH proteomics identified 109 differentially expressed proteins in total exosomes and 46 in placenta-derived exosomes.
• Key hub proteins HRG, VWF, and PIGR were identified and verified by Western blotting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 23.1 KB, indicating a limited scope likely focused on summary or analysis results rather than raw measurements.

Provenance

Source

figshare, author Yuxuan Jiang

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:46; freshness should be verified.