ANCA Vasculitis Cardiovascular Risk: Propensity-Matched Cohort Study

20,422 patients with granulomatosis with polyangiitis (GPA) and 5,907 with microscopic polyangiitis (MPA) were analyzed from the TriNetX electronic health records network. Sebastian Klapa published this retrospective cohort study on figshare in April 2026, comparing mortality and cardiovascular outcomes against matched controls.

Use Cases

• Calculate hazard ratios for mortality based on patient cohorts
• Compare cardiovascular event risks between GPA and MPA subtypes
• Analyze thromboembolic event incidence using propensity-matched controls
• Study major adverse cardiovascular events (MACE) in vasculitis populations

Strengths

• 26,329 total patient records for GPA and MPA
• Propensity score matching for demographic and comorbidity variables
• Hazard ratios calculated for death and cardiovascular outcomes

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

TriNetX network electronic health records database

Collection Method

Retrospective cohort analysis with propensity score matching

Freshness

Last updated 2026-04-15 05:46:00; freshness should be verified

Geography

United States