KCNB1 Regulatory Variants: BMI-Associated SNPs from Admixed Brazilian GWAS

1,079 admixed Brazilian individuals were analyzed in a genome-wide association study for body mass index. Samantha Kuwada Teixeira published the results on figshare in May 2026, identifying three loci reaching genome-wide significance. The dataset likely contains prioritized variants, such as rs149309426, and associated functional analysis results.

Use Cases

• Identify ancestry-informative BMI-associated variants based on GWAS results from an admixed population
• Analyze the relationship between regulatory variants and adipogenesis based on functional characterization data
• Compare allele frequencies of obesity risk variants across different ancestries based on enrichment analysis
• Investigate enhancer-promoter interactions for KCNB1 based on chromatin conformation data mentioned in the description

Strengths

• Includes GWAS results from 1,079 admixed Brazilian individuals, a population underrepresented in obesity genetics
• Integrates functional validation data from luciferase assays, EMSA, and animal models
• Published under a CC-BY-4.0 license, allowing for reuse and redistribution

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is 11.1 KB, indicating a very limited scope likely containing summary results rather than raw data

Provenance

Source

figshare

Collection Method

Genome-wide association study (GWAS) and integrative functional analysis

Freshness

Last updated 2026-05-07 04:44:57

Geography

Admixed Brazilian population