Table 7_Association between circulating biomarkers of one-carbon metabolism and glymphatic

210 participants, including 68 with normal cognition, 75 with mild cognitive impairment due to AD, and 67 with dementia due to AD, were enrolled in this study by Yali Chen, last updated in May 2026. It investigates the relationship between circulating biomarkers of one-carbon metabolism and glymphatic system function, measured via the DTI-ALPS index. The findings suggest a potential association between metabolic status and glymphatic function linked to cognitive performance in Alzheimer's disease.

Use Cases

• Correlating serum folate levels with neuroimaging-based glymphatic function indices.
• Investigating sex-specific differences in biomarker levels and cognitive outcomes.
• Modeling the combined risk of low folate and low DTI-ALPS index on domain-specific cognitive performance.
• Analyzing associations between homocysteine, vitamin B12, and glymphatic system function.

Strengths

• Includes data from 210 participants across three clinical groups.
• Measures multiple circulating biomarkers (folate, vitamin B12, homocysteine) and a neuroimaging index (DTI-ALPS).
• Reports statistically significant correlations (e.g., r=0.212 between folate and DTI-ALPS index).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The cross-sectional nature of the study, as noted in the conclusion, limits causal inference.

Provenance

Source

Yali Chen via figshare.

Collection Method

Clinical study enrolling participants and measuring serum biomarkers and neuroimaging indices.

Freshness

Last updated 2026-05-11 04:29:25; freshness should be verified.