Table 7_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

A 2026 study by Zhan Li analyzes the association between NDRG4 gene methylation in peripheral blood leukocytes and gastric cancer. The dataset includes results from a two-phase case-control study with 310 gastric cancer patients and 300 controls, along with bioinformatics analyses from TCGA and GEO databases. It reports odds ratios for cancer risk and associations with chemotherapy efficacy and patient survival.

Use Cases

• Assessing gastric cancer risk based on methylation levels at specific NDRG4 CpG sites mentioned in the description
• Investigating the relationship between gene methylation and chemotherapy efficacy in gastric cancer patients
• Analyzing the prognostic value of NDRG4 methylation for patient progression-free survival
• Studying the correlation between the rs7202037 SNP genotype and NDRG4 gene methylation levels

Strengths

• Includes data from a two-phase case-control study with 310 patients and 300 controls, providing a basis for statistical analysis
• Reports specific odds ratios and confidence intervals for cancer risk associated with two CpG sites
• Integrates findings from public bioinformatics databases (TCGA and GEO) with original clinical study data

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment
• The dataset is very small at 19.1 KB, indicating limited scope and likely summary-level results
• Description metadata is limited; actual data quality and structure require manual inspection after download

Provenance

Source

figshare, author Zhan Li

Collection Method

Bioinformatics analysis of TCGA and GEO databases combined with a two-phase clinical case-control study

Freshness

Last updated 2026-04-27 04:12:24