Bioinformatics Analysis of Bushen Anzhi Recipe for Aging-Related Insomnia

A 9.5 KB Excel dataset from a 2026 figshare upload by Haiming Li. It contains bioinformatics analysis results investigating the mechanisms of a Traditional Chinese Medicine formula for treating aging-related insomnia. The data is derived from 555 samples in the GSE98582 insomnia dataset and experimental results from a rat model study.

Use Cases

• Identify potential drug-target interactions based on the 25 effective components and 16 overlapping target genes mentioned.
• Analyze gene enrichment and pathway regulation, focusing on core targets like HIF1A, PTGS2, and GSK3B described in the results.
• Correlate behavioral and polysomnography outcomes from the rat model with molecular changes in the Wnt signaling pathway.

Strengths

• Clear experimental design described, involving 60 rats across three control and treatment groups.
• Analysis integrates data from multiple public databases (GeneCards, MSigDB, TCMSP, HERB).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 9.5 KB file size suggests a very limited scope, likely containing summary results rather than raw data.

Provenance

Source

figshare, author Haiming Li

Collection Method

Bioinformatics analysis of public gene expression data (GSE98582) combined with experimental validation in a rat model.

Time Range

Publication date 2026, but underlying gene expression data collection date is unknown.

Freshness

Last updated 2026-05 08 05:54:38; freshness should be verified.

Geography

Likely China, given the focus on Traditional Chinese Medicine, but not explicitly stated.