ART Effects on Alveolar Macrophages: Single-Nucleus Transcriptomic and Epigenetic Data

A 13.5 MB Excel dataset from a 2026 figshare study investigates the long-term impact of continuous antiretroviral therapy (ART) on alveolar macrophages. The data likely contains single-nucleus level transcriptomic and epigenetic measurements linking ART duration to a progressive senescence-like state. Author Vinicius M. Fava's research suggests these ART-induced changes are independent of HIV infection and impair immune response to pathogens like SARS-CoV-2.

Use Cases

• Modeling the relationship between ART duration and cellular senescence markers based on transcriptomic priming data.
• Analyzing coordinated gene regulatory networks in alveolar macrophages based on single-nucleus level transcription factor linkages.
• Investigating the impact of ART on interferon signaling and antiviral response pathways mentioned in the description.
• Comparing ART-induced epigenetic alterations between people with HIV and those on pre-exposure prophylaxis (PrEP).

Strengths

• Dataset is 13.5 MB in size, indicating a substantial amount of structured data.
• The underlying study employs a systems immunology approach, suggesting multi-modal data integration.
• Findings are explicitly linked to ART duration and a secondary effect on interferon signaling, providing clear research variables.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely generated from a systems immunology study evaluating alveolar macrophages using single-nucleus analyses.

Freshness

Last updated 2026-04-22 05:49:06