Influenza A(H1N1) Hemagglutinin Mutations and Co-detection Records from 2000-2025

An evidence-mapping synthesis integrates bibliometric analysis and sequence data for Influenza A(H1N1). The work is based on 11,848 unique publications and GenBank-derived hemagglutinin sequences. It was authored by Xinrui Cao and last updated in March 2026.

Use Cases

• Analyze post-2010 shifts in hemagglutinin mutational patterns at sites like S13, S146, S160, and S202.
• Map literature-derived co-detection records to identify frequently reported co-pathogens such as RSV and SARS-CoV-2.
• Examine structural features of hemagglutinin, including the conformationally flexible segment spanning residues aa190–aa226.
• Investigate specific mutations like G219A in Eurasian avian-like H1N1 strains within the receptor-binding region.

Strengths

• Integrates 11,848 unique publications from PubMed, Web of Science, and Scopus.
• Covers a 25-year time range from 2000 to 2025.
• Uses GenBank-derived hemagglutinin sequences and Swiss-Model homology models for structural analysis.

Limitations

• The dataset is small at 1.4 MB, primarily containing a document with synthesized findings rather than raw data.
• Literature-derived co-detection records reflect heterogeneous study reporting rather than population-level prevalence.
• Specific row counts for sequence or co-detection records are not provided.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis, expert-guided curation, and sequence/structure-informed interpretation.

Time Range

2000–2025

Freshness

Last updated on 2026-03-26.

Geography

Global, with a specific module focused on China.