Herpes Zoster Pain Outcomes Linked to VZV Genotypes and gE Mutations

Chongqing-based study of 52 herpes zoster outpatients, with 46 sequenced samples, investigating varicella-zoster virus genotypes and glycoprotein E mutations. Ying Shi authored this research, which integrates clinical data and immunological indicators to build a predictive model for pain relief outcomes. The dataset was last updated on April 29, 2026.

Use Cases

• Predicting poor pain relief outcomes based on gE-related variables and immunological markers.
• Analyzing associations between VZV genotypes (Clade 2, 3, 4, etc.) and clinical pain burden.
• Investigating the role of specific gE gene mutations (e.g., T→I substitution) in host immune responses.
• Developing L1-regularized regression models for clinical stratification of herpes zoster patients.

Strengths

• Includes 46 sequenced VZV samples from a cohort of 52 herpes zoster patients.
• Provides detailed mutation counts (average 13.46 ± 8.07 mutations) and deletion counts (average 5.00 ± 3.71 deletions).
• Model performance metrics are reported (AUC = 0.87; PR-AUC = 0.74).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the Chongqing patient cohort.

Provenance

Source

figshare

Collection Method

Clinical data and immunological indicators collected from herpes zoster outpatients; VZV genotyping performed via SNP analysis of ORF22 region; gE gene mutations analyzed by PCR and sequencing.

Freshness

Last updated 2026-04-29 05:58:18; freshness should be verified.

Geography

Chongqing, China