Table 7_Identification of a prognostic signature based on ammonia metabolism-related genes

6 prognostic genes (RGS20, ADA, AICDA, SLC12A5, RUFY4, CDK5RAP3) were identified for clear cell renal cell carcinoma (ccRCC) through an integrated analysis of bulk and single-cell transcriptomic data. The dataset, created by Yao Jiang and last updated in April 2026, contains results from a risk model, functional enrichment, immune infiltration, and somatic mutation analyses. It is a small dataset, 305.8 KB in size, shared under a CC-BY-4.0 license.

Use Cases

• Validating prognostic risk scores for ccRCC patients based on the 6-gene signature.
• Investigating immune cell infiltration differences between high-risk and low-risk patient groups.
• Analyzing cell communication patterns, particularly between malignant cells and T cells, as described in the single-cell analysis.
• Studying the role of ammonia metabolism-related genes in cancer progression and cell death pathways.

Strengths

• The prognostic model is based on an integrated analysis of both bulk and single-cell transcriptomic data.
• Results were validated with Reverse transcription quantitative PCR (RT-qPCR), showing consistent upregulation of the 6 genes (p < 0.05).
• Analysis includes multiple dimensions: functional enrichment, immune infiltration, and somatic mutation profiling.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset's 305.8 KB size suggests it contains summary or model results, not the raw underlying transcriptomic data.
• Freshness should be verified; the last update is listed as 2026-04-23, which is a future date.

Provenance

Source

Transcriptomic data retrieved from public resources, as stated in the description.

Collection Method

Integrated analysis of bulk and single-cell transcriptomics using differential expression, machine learning for prognostic gene filtering, and subsequent validation assays.

Freshness

Last updated 2026-04-23 05:35:58; freshness should be verified.