Chronic Hepatitis B Immune-Active Phase Hub Gene Identification

Fangfang Li published this dataset on 2026-05-04. It contains results from a bioinformatics and machine learning analysis identifying hub genes specific to the immune-active phase of chronic hepatitis B. The data includes four identified hub genes, such as SLC24A4, validated via single-cell RNA sequencing and clinical samples.

Use Cases

• Validate hub gene expression patterns in chronic hepatitis B based on the identified genes CCR5, IL10RA, KCNA3, and SLC24A4.
• Perform immune infiltration analysis based on the described correlation between SLC24A4 and macrophage subtypes.
• Conduct in silico knockout studies for target genes like SLC24A4 based on the described methodology.
• Screen for FDA-approved drug candidates targeting specific hub genes based on the virtual screening approach mentioned.

Strengths

• Identifies four specific hub genes (CCR5, IL10RA, KCNA3, SLC24A4) with validation from two independent scRNA-seq datasets.
• Analysis integrates multiple methods: differential expression, WGCNA, machine learning, and clinical sample validation.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 13.1 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Integrated bioinformatics and machine learning analysis of transcriptomic dataset GSE230397, validated with scRNA-seq datasets GSE182159 and GSE283471 and western blot.

Time Range

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Freshness

Last updated 2026-05-04 05:31:09; freshness should be verified.

Geography

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