Common Genes Associated with Diabetic Nephropathy and Retinopathy

206 common genes were identified from transcriptome data GSE185011, intersecting 526 diabetic nephropathy and 1,059 diabetic retinopathy differentially expressed genes. The dataset includes 6 diagnostic genes for diabetic nephropathy and 4 for diabetic retinopathy, resulting from LASSO analysis and enrichment studies. Author Juan He published this dataset on figshare under a CC-BY-4.0 license, last updated on 2026-04-28.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified diagnostic genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic nephropathy and retinopathy based on the 206 common genes.
• Analyzing immune cell infiltration differences, such as central memory CD4 T cells and activated B cells, between disease groups.
• Constructing regulatory networks based on the described TF-mRNA-miRNA interactions, including the key TF EGR1.

Strengths

• Identifies 206 common genes from intersecting 526 and 1,059 differentially expressed gene sets.
• Screens specific diagnostic gene sets: 6 for diabetic nephropathy and 4 for diabetic retinopathy.
• Includes results from enrichment, LASSO, GSEA, and immune infiltration analyses described in the study.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 19.1 KB, indicating limited scope.

Provenance

Source

figshare, author Juan He.

Collection Method

Analysis of transcriptome data GSE185011 using differential expression, intersection, enrichment, LASSO, and network construction methods.

Freshness

Last updated 2026-04-28 05:24:48; freshness should be verified.