ISR-Related Prognostic Genes for High-Grade Serous Ovarian Cancer

Research by Qian Li, published on figshare in 2026, identifies four integrated stress response-related prognostic genes for high-grade serous ovarian cancer. The dataset likely contains results from Mendelian randomization, single-cell, and bulk RNA sequencing analyses used to build a risk model. The file is 14.2 KB in size and was last updated on 2026-05-05.

Use Cases

• Validate prognostic gene signatures based on the identified genes NUP35, CASP3, BAG5, and DNAJB1.
• Investigate drug sensitivity correlations based on the described link between DNAJB1 expression and NPK76-II-72–1.
• Explore epithelial cell differentiation dynamics based on the described expression changes of BAG5 and DNAJB1.
• Analyze pathway enrichment in cancer risk groups based on the reported significance of the PPAR signaling pathway.

Strengths

• Dataset is derived from a multi-method study integrating Mendelian randomization, single-cell, and bulk RNA sequencing.
• Results were validated with RT-qPCR, western blotting, and immunohistochemical staining.
• File is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 14.2 KB, indicating limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, author Qian Li.

Collection Method

Integrated analysis of HGSOC- and ISR-related data using differential expression, Mendelian randomization, and Cox analyses.

Freshness

Last updated 2026-05-05 05:24:59; freshness should be verified.